Feb 17 2014
Date: February 24, 2014 (Monday)
Time: 12:45 p.m. to 1:45 p.m.
Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital
Presenter: Ms. Rao Ninajing, PhD Candidate (12:45 p.m. to 1:15 p.m.)
Title: Study on the pathogenesis of Bisphosphonate-related Osteonecrosis of the jaws
Abstract: Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a rare but severe clinical complication related with Bisphosphonates (Bps) therapy, which is widely used for management a series of conditions accompanied by pathologically high bone resorption, such as Paget’s disease, osteoporosis and bone metastasis. And so far the underlying pathogenesis of BRONJ is still unknown. According to the relevant researches, multiple correlating factors might get involved in the development of BRONJ, including the efficacy and cumulative amount of Bps, dental surgical procedures as well as dental infection. The aim of the present study is 1) to assess the significance of periapical infection in the development of Bisphosphonate-related osteonecrosis of the jaws and further explore its underlying pathophysiological mechanisms; 2) To assess the significance of Actinomyces onto the development of BRONJ. 80 12-weeks-old female C57BL/6N ovariectomized mice will be used in the study, 20 animals in each group. Clinical examination, Micro-CT scanning, immunohistochemistry will be used to observe morphological and histopathologic changes of jaw bones in this study.
Presenter: Mr. Huo Lei, PhD Candidate (1:15 p.m. to 1:45 p.m.)
Title: Effect of bisphosphonate on periodontal condition in compromised host
Abstract: Bisphosphonate related osteonecrosis of the jaw (BRONJ) has been reported as a serious complication on the patients received bisphosphonate treatment. The usage of this drug is mainly 1) low dose to enhance bone strength in postmenopausal women and aged people; 2) high dose to prevent and treat malignant skeletal complications in cancer patients. Although it is widely accepted that high-dose bisphosphonate is a high-risk factor in inducing osteonecrosis, some studies demonstrated potential advantage of low-dose bisphosphonates in inhibiting alveolar bone resorption in progressive periodontitis. The objectives of this study are to investigate the effect of high and low doses bisphosphonates on periodontal condition using an ovariectomized rat model, and the risk of high/low doses bisphosphonates in inducing osteonecrosis in compromised host with progressive periodontitis. Clinical examination, Micro-CT, TUNEL staining, histology, immunohistochemistry and immunofluorescence labeling will be used to investigate morphological and histopathologic changes of jawbones under various experimental conditions.
No responses yet| 97 views