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Jun 17 2014

Dental Research Seminar

Published by Dental Library under Dentistry
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Date: June 23, 2014 (Monday)

Time: 12:45 p.m. to 1:30 p.m.

Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

 

Presenter: Ms. Ma Xiaomin, PhD Candidate

Title: Effects of Silver Diamine Fluoride in Preventing Dental Caries in Patients Wearing Removable Partial Dentures: A Randomized Double-blind, Placebo-controlled Study 

Abstract: Removable partial dentures (RPDs) are commonly used to replace missing teeth in adult patients. However, patients wearing dentures may have an increased rate of dental decay. The effect of topical fluoride on caries prevention in RPD wearers have not been evaluated in previous studies. The aim of this study is to compare the effectiveness of semi-annually applied silver diamine fluoride versus placebo on dental caries prevention and the quality of oral flora in patient wearing RPDs over a two-year period.

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Jun 12 2014

Dental Research Seminar

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Date: June 18, 2014 (Wednesday)
Time: 12:45 p.m. to 1:30 p.m.
Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

Presenter: Mr. Yang Ning, PhD Candidate

Title: The stringent response in Staphylococcus aureus and related bacterial pathogens

Abstract: The stringent response is a coordinated regulatory process initiated by all bacterial species in response to starvation or environmental challenges, such as oxidative stress or antibiotic administration. In this talk, I will give an overview of the mechanisms underlying the stringent response, with particular emphasis to the major bacterial pathogen Staphylococcus aureus. I will outline the key molecular processes that remain to be fully elucidated, and will indicate how these issues may be addressed.

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May 28 2014

Dental Research Seminar

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Date: June 4, 2014 (Wednesday)
Time: 12:45 p.m. to 1:45 p.m.
Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

Presenter: Miss Wang Shuai, PhD Candidate (12:45 p.m. to 1:15 p.m.)

Title: Effects of Enterococcus faecalis and Lipoteichoic Acid from Enterococcus faecalis on osteoblasts and osteoclasts

Abstract: Enterococcus faecalis is considered a major pathogen related to refractory root canal infection. E. faecalis colonize dentin and form biofilms in endodontically treated teeth with periapical lesions. Lipoteichoic acid (LTA) is a principal component of bacterial membrane and a major virulence factor of E. faecalis. LTA can cause apoptosis in osteoblasts and osteoclasts and stimulates leukocyte to release pro-inflammatory cytokines and bone resorption. Semaphorin 4D (Sema4D), is a mediator of osteoclast-osteoblast communication. Sema4D-Plexin-B1 bidirectional signaling plays a critical role in the suppression of osteoblast differentiation. In our present study, we for the first time have found that E. faecalis LTA induced the immune-inflammatory response of human macrophages via TLR-2 dependent NF-κB and p38 signal transduction. Furthermore, E. faecalis enhanced osteoclastogenesis with upregulation of Sema4D expression. Further studies are needed to explore the mechanisms of E. faecalis and E. faecalis LTA involved in osteogenensis, osteoclastogenesis and bidirectional signaling in bone remodeling.

 

Presenter: Mr. Jin Xiaozhuang, PhD Candidate (1:15 p.m. to 1:45 p.m.)

Title: Universal primers: Development and adhesion aspects for resin-metal bonding

Abstract: Currently, no single bonding agent could bond universally dental acrylic-based resin to metals. Recently, the novel silane system (NSS) primers were reported by Matinlinna and co-workers that could promisingly to promote the bonding between the resin and some dental biomaterials e.g. titanium and amalgam. NSS primers sought to provide a durable and hydrolytic stable bonding permanently. However, the adhesion mechanism and optimal formulation of NSS primers are not yet studied. Thus, in the current study, the mechanical, chemical and physical properties of such NSS primers would be studied in order to understand fundamentally the adhesion mechanism, and improve the NSS primers performance in acrylic-based resin to metal bonding. In addition, optimized NSS primers formulations which could universally enhance the bonding between acrylic-based resin and metals in both dental and medical systems are targeted. 

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May 27 2014

Dental Research Seminar

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Date: June 3, 2014 (Tuesday)
Time: 12:45 p.m. to 1:45 p.m.
Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

 

Presenter: Miss Xie Shujie, PhD Candidate (12:45 p.m. to 1:15 p.m.)

Title: Functional Characterization of a Phage-derived Exonuclease and DNA Recombination Protein from an Oral Neisseriaceae

Abstract: Two-component DNA homologous recombination systems comprising a DNA exonuclease and single strand DNA annealing protein (SSAP) are widely distributed throughout the prokaryotic world. Such DNA homologous recombination systems have been utilized in in vivo genetic engineering procedures – termed ‘recombineering’ – which can be used to modify plasmid or genomic DNA within bacterial cells. Based on their amino acid sequences, ‘YqaJ’ proteins have been predicted to comprise a distinct type of DNA exonuclease, within the large Lambda-Exo family of exonucleases. However, no YqaJ protein homologue has yet been functionally characterized. Here, I describe the comprehensive characterization of a YqaJ protein (KO-YqaJ) and partnering SSAP protein (KO-RecT) from Kingella oralis, a commensal species of oral Neisseriaceae. My experiment results clearly show that the KO-YqaJ and KO-RecT proteins have DNA recombination activities in bacterial cells, thus demonstrating their potential for use in recombineering applications. Taken together, data indicates that ‘YqaJ’ family exonuclease proteins are functionally equivalent to ‘Exo’ family proteins, but have several notable differences. Thus, my work shows that YqaJ proteins constitute a distinct class of DNA exonuclease.

 

Presenter: Mr. Li Peng, PhD Candidate (1:15 p.m. to 1:45 p.m.)

Title: Survival mechanism of microbial biofilm persisters and their interaction with the host

Abstract: Biofilm has been recognized as the predominant mode of microbial growth and exhibits higher drug resistance compared to its planktonic counterpart. The ability of pathogens to form biofilms is a leading cause for persistence of infections and failure of antibiotic therapy. A subpopulation of biofilms named “persisters” can survive from killing of lethal-dose antimicrobials. Persisters are phenotypic variants which are highly tolerant to multiple antimicrobials without acquiring genetically heritable resistance. The biological basis of persisters has been elusive and little is known about the interaction between biofilm persisters and the host cells. The present study focuses on the bacterial and fungal biofilm persisters of P. gingivalis and C. albicans to investigate the survival mechanism of microbial biofilm persisters and their interactive profiles with the host.

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May 23 2014

Dental Research Seminar

Published by Dental Library under Dentistry
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Date: May 30, 2014 (Friday)

Time: 12:45 p.m. to 1:30 p.m.

Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

                                                          

Presenter: Miss Zhang Shinan, PhD Candidate

 

Title: Oral health status, knowledge and behaviors of Dai and Bulang ethnic minority groups in Yunnan Province, China

 

Abstract: An oral health survey was conducted on a sample of 5- and 12-year-old Dai and Bulang children in Yunnan, China. The dental caries prevalence among the 5-year-old Dai and Bulang children was 89% and 85%, respectively. Most of the decay were left untreated. The caries experience of the 5-year-old Dai children was associated with gender, father’s education, bottle feeding habits, snacking habits, dental visit behaviour, and oral hygiene status. The caries experience of the 5-year-old Bulang children was associated with their snacking habits, dental visit habits and oral hygiaene status. The dental caries prevalence of the 12-year-old Dai and Bulang children was 40% and 35%, respectively and most of the caries were untreated. Dental caries among the 12-year-old Dai and Bulang children and associated with gender and dental attendance. Their oral health-related knowledge was moderate. Most of them had gingivitis and around half of them had dental calculus.

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May 22 2014

Dental Research Seminar

Published by Dental Library under Dentistry
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Date: May 29, 2014 (Thursday)

Time: 12:45 p.m. to 1:30 p.m.

Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

 

 

Presenter: Mr. Hamama Hamdi Hosni Hamdan Eldesouki, PhD Candidate

Title: Chemomechanical Caries Removal : Is it a Fact or a Science Fiction?

 

Abstract: Chemomechanical caries excavation is an excellent example of conservative caries removal methods due to its ability to reliably preserve a greater thickness of caries-affected dentine. Chemomechanical caries removal agents dissolve the denatured collagen fibrils leaving the sound and partially-degraded fibrils intact. Also, one of the main advantages of the CMCR method is its characteristic visual excavation end point sign, after this point, the solution fails to become turbid. The aim of this PhD project was to evaluate the efficacy of currently available chemomechanical caries removal  methods and its effects on tooth substrate, residual bacteria, and bonding to dentine.

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Mar 21 2014

Dental Research Seminar

Published by Dental Library under Dentistry
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Date: March 28, 2014 (Friday)

Time: 12:45 p.m. to 1:15 p.m.

Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

 

Presenter: Ms. Epasinghe Don Jeevanie, PhD Candidate

 

Title: Potential Applications of Proanthocyanidin for Reparative Therapies in Dentistry

 

Abstract: In dentistry, repair and restoration of tooth structure to regain its mechanical properties is the ultimate aim of caries management. Since collagen is the major part of dentine it is necessary to strengthen and preserve collagen matrix when repairing lesions involved in dentine. Proanthocyanidin is a naturally derived collagen cross linker which can strengthen and protect the collagen fibers from degradation. The present study aimed to investigate the potential applications of proanthocyanidin in dentistry.

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Mar 20 2014

Dental Research Seminar

Published by Dental Library under Dentistry
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Date: March 27, 2014 (Thursday)

Time: 12:45 p.m. to 1:30 p.m.

Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

                                                          

Presenter: Dr. Leung Yiu Yan, PhD Candidate

 

Title: Prevention and treatment of neurosensory disturbance after lower third molar surgery

 

Abstract: Neurosensory deficit is a well-reported complication after lower third molar surgery. It is useful to know the outcomes of the available treatments for neurosensory deficit after third molar surgery. It is more important to prevent nerve injury from third molar surgery. A study on quality of life and psychological well-being was conducted to investigate their impact on patients with permanent neurosensory deficit after lower third molar surgery. The result of a study on the longitudinal outcome of microsurgical repair after nerve injury from lower third molar surgery will be presented. The long-term safety of coronectomy of lower third molar was investigated and the morbidities and root behavior will be presented.

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Mar 17 2014

Dental Research Seminar

Published by Dental Library under Dentistry
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Date: March 24. 2013 (Monday)
Time: 12:45 p.m. to 1:45 p.m.
Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital
 
Presenter: Miss Guo Yan, PhD Candidate (12:45 p.m. to 1:15 p.m.)

Title: Aspects of Charge Generation on Ti Surface using a Triboelectric Approach

Abstract: Titanium and its alloys have been widely used as a material for dental subgingival implants, and one main reason is their unique ability to osseointegrate with the host bone. The rate and quality of osseointegration of a titanium dental implant depends strongly upon its surface properties. A negative charge has been known to promote the osseointegration of titanium. The current investigations revealed that sandblasting can generate a negative charge on the surface of Ti substrates, due to the triboelectric effect. The same was observed with Ti and stainless steel mini orthodontic implants studied.

The results of the current study suggested that sandblasting could generate static charges on titanium and stainless steel surfaces. However, such charges gradually dissipate into the atmosphere. The amount, polarity, and the decay rate of the charge depend on many factors tested in the experiments. These obtained results might help explaining the beneficial effects of sandblasting on the osseointegration of titanium implants.

 
Presenter: Mr. Liu Dan, PhD Candidate (1:15 p.m. to 1:45 p.m.)

Title: Some Surface Treatments for Improving the Durability of Zirconia-Based Restorations

Abstract: Although zirconia has been increasingly used in modern dental practice, the application of zirconia-based dental restorations is still constrained by the relatively weak bonding. This includes porcelain to zirconia bonding, and resin to zirconia bonding. The current laboratory study was aiming to evaluate the effects of some new modified surface treatments on the adhesion durability of dental zirconia.

It was found that porcelain zirconia bonding could be effectively enhanced by applying both sandblasting and a new laser irradiation approach. Laser irradiation might be a potential approach as a surface treatment for improving the quality of porcelain zirconia bonding. Strong and reliable resin zirconia integration could not be achieved without appropriate surface pre-treatment. The new coating treatment is a promising approach for strengthening resin to zirconia adhesion.

No responses yet| 120 views

Mar 12 2014

Dental Research Seminar

Published by Dental Library under Dentistry
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Date: March 19, 2014 (Wednesday)
Time: 12:45 p.m. to 1:45 p.m.
Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

 

Presenter: Mrs. Gao Wenling, PhD Candidate (12:45 p.m. to 1:15 p.m.)

Title: The Diversity of Subgingival Microbiota in Periodontal Pockets

Abstract: Periodontal disease is a spectrum of infectious inflammatory diseases of the periodontium, which result from an inappropriate interaction between the subgingival microbes and adjacent tissues. It has a highly complex etiology, as the composition of microbial biofilms is vast and highly variable. Many microbes in subgingival plaque cannot yet be cultivated, and so molecular approaches are widely considered to be the most effective methods for analyzing its composition. This study aims to use contemporary molecular-based approaches, such as high throughput DNA sequencing, to investigate subgingival bacteria diversity within subjects with chronic and aggressive forms of periodontitis, gingivitis compared to those with good periodontal health. Particular focus will be given to oral spirochetes, such as the red complex bacterium Treponema denticola, which has consistently been observed to be prevalent within diseased periodontal pockets.

 
Presenter: Mr. Hui Xiang, PhD Candidate (1:15 p.m. to 1:45 p.m.)

Title: Periodontal resident cell autophagy modulated by LPS pattern recognition and tissue hypoxia

Abstract: Periodontitis is a gram-negative microbes-induced chronic inflammation that destroys tooth-supporting structures. The mechanism of disease initiation remains not fully understood. Autophagy is a conserved cellular process essential for development and inflammation. The role, if any, of autophagy in periodontitis pathogenesis was not clear. This study aims to investigate the role of autophagy in periodontal resident cell, including endothelial cell, in growth, survival, differentiation and migration with special emphasis on relationship between TLR4 signaling and/or hypoxia.

No responses yet| 90 views

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