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Dec 16 2014

Dental Research Seminar

Published by Dental Library under Dentistry
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Date: December 23, 2014 (Tuesday)
Time: 12:45 p.m. to 1:30 p.m.
Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

Abstract: Long term care institutions face a formidable challenge with the projected increase in the population of dependent elders in the coming decades. Poorer oral health has been consistently observed amongst institutionalized elders compared to community-dwelling elders, and this has been attributed to a number of factors including compromised physical and mental capabilities, resulting in a general loss of functional independence. This is further compounded by a general lack of awareness and neglect of oral hygiene by nursing home staff, whom residents depend on for the majority of their daily selfcare. Absence of daily oral hygiene results in the build-up of dental plaque and allows the uninhibited growth of opportunistic bacteria, which have been shown to cause lower respiratory tract infections such as aspiration pneumonia, one of the most common infectious causes of death among institutionalized elders. While there is a general consensus that an antimicrobial agent should be used as part of an optimal daily oral hygiene regimen in institutionalized elders, agreement has yet be reached regarding the optimal agent and its method of application. Delivery of an antimicrobial agent as a mouthwash may be problematic for frail elders who may be mentally impaired and unable to follow instructions, or have swallowing impairments and at a risk for aspiration. The use of an oral spray has been shown to be effective in other patient groups, and may be more appropriate and applicable for institutionalized elders. While chlorhexidine serves as the gold standard for anti-plaque effectiveness, prolonged usage is contraindicated due to side effects which include tooth staining and calculus formation. Chlorine dioxide is an effective antimicrobial agent, and short term studies have suggested a comparable anti-plaque activity compared to chlorhexidine, as well as the absence of these side effects. We  now propose to test the effectiveness of a chlorine dioxide spray against a chlorhexidine spray in the reduction of dental plaque, oral respiratory pathogens, and incidence of aspiration pneumonia amongst institutionalized elders. All participants will be expected to benefit from the administered interventions, and we hope to develop an optimal oral hygiene protocol which can easily be adopted at a low cost by nursing homes regionally in Hong Kong, and potentially worldwide.

Presenter: Mr. Zhang Jiaguan, MPhil Candidate
Title: A randomized clinical trial on the effect of a chlorine dioxide spray on dental plaque and respiratory pathogens in institutionalized elders

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Nov 10 2014

Dental Research Seminar

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Date: November 17, 2014 (Monday)
Time: 12:45 p.m. to 1:30 p.m.
Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

Presenter: Ms. Li Lingwei, PhD Candidate

Title: A longitudinal study of obesity and dental caries among Hong Kong adolescents

Abstract: Obesity greatly impacts adolescents’ physical and psychological health. Obesity and dental caries are thought to share a common pathogenesis in nutrition, parenting, lifestyle, physical, social environment, as well as psychosocial factors. Studies have been conducted among various countries to investigate the relationship between adiposity and tooth decay. However, most of these studies were performed in a cross-sectional setting and indicated conflicting findings. The aim of this study is to investigate the relationship between obesity and dental caries among Hong Kong adolescents over time. In this seminar, a systematic review will be presented to highlight the current research status. The methodology of the present study will also be introduced.

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Oct 08 2014

Dental Research Seminar

Published by Dental Library under Dentistry
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Date: October 15, 2014 (Wednesday)
Time: 12:45 p.m. to 1:30 p.m.
Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

Presenter: Mr. Wu Zhaoming, MPhil Candidate

Title:The role of TRAF-interacting protein (TRAIP) during craniofacial development

Abstract: The control of cell proliferation is crucial for the craniofacial development. But the mechanism of how the cell proliferation is coordinated during the development remains to be elucidated. The TRAF-interacting protein (TRAIP) is an E3 ubiquitin ligase, which plays a role in cell proliferation and differentiation. It has also found been to interact with the cell cycle related protein PCNA. In this study the expression pattern of TRAIP during different stages of craniofacial development will be investigated and its potential relationship with cell proliferation will be evaluated. Its potential upstream and downstream signals will also be explored.

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Sep 22 2014

Dental Research Seminar

Published by Dental Library under Dentistry
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Date: September 26, 2014 (Friday)
Time: 12:45 p.m. to 1:30 p.m.
Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

Presenter: Dr. Bhoj Manasi, MPhil candidate

Title: De novo bioengineering of a pulp replacement using stem cell-seeded RGD alginate based micro environments

Abstract: The aim of the study was to create a three-dimensional pulp stem cell seeded construct infused with inductive tissue specific growth factors VEGF121 and FGF-2 in an alginate scaffold supplemented with dental pulp stem cells (DPSC) and human umbilical vein endothelial cells (HUVEC). The combination of these elements into a single system in the core of the construct for inducing angiogenesis and further coating the construct with another layer thereby initiating dentinogenesis is an innovative design for the formation of de novo pulp tissue in vitro. Four study groups with different permutation and combination were fabricated replicating the gutta-percha shape, later analyzed for proliferation, viability and growth factor release profile. The results of the first study show significant difference in groups supplemented with morphogens with a p value a potential for dental pulp regeneration

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Sep 10 2014

Dental Research Seminar

Published by Dental Library under Dentistry
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Date: September 17, 2014 (Wednesday)

Time: 12:45 p.m. to 1:30 p.m.

Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

Presenter: Mr. Ekambaram Manikandan, PhD Candidate

Title: Aspects of solvent on dentin bonding

Abstract: Degradation starts at the resin-dentin bonded interfaces within a few months of adhesive bonding.  The simplified dental adhesives that are routinely used in the contemporary clinical dental practice are extremely hydrophilic and are prone to hydrolytic degradation. Matrix metalloproteinases (MMP) and cysteine cathepsins (CC) are the two types of proteolytic enzymes that have been shown to degrade the un-infiltrated demineralized collagen at the bottom of the hybrid layer in the bonded interfaces. These enzymes are hydrolases; therefore, the presence of water in the hybrid layer will be a favourable factor for degradation of the dentin-bonded interfaces. Ethanol-wet bonding (EWB) with hydrophobic adhesive could prevent the hydrolytic degradation of dentin bonded interfaces. In vivo and in vitro studies have shown that chlorhexidine (CHX) treatment of demineralized dentin prior to resin bonding preserved resin-dentin bond durability by inhibition of dentin-matrix bound MMP and CC. However, water in the hybrid layer could lead to easier removal of CHX from demineralized dentin, when compared to ethanol. 1-Ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride (EDC) is a dentin collagen cross-linker shown to preserve dentin bond durability in vitro. EDC solution for dentin collagen crosslinking is routinely prepared in water, though water incorporation in the hybrid layer would lead to dentin bond degradation. Our research experiments aimed to study the role of alternative solvents in the current experimental strategies for the enhancement of resin-dentin bond durability. Within the limitations of our research work, it could be concluded that solvents play a significant role in the enhancement of dentin bond durability. The choice of solvent depends on the bonding protocols applied. In general, ethanol and acetone are better than water for preservation of resin-dentin bond durability.

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Aug 28 2014

Dental Research Seminar

Published by Dental Library under Dentistry
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Date: September 4, 2014 (Thursday)
Time: 12:45 p.m. to 1:45 p.m.
Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

Presenter: Ms. Zhuang Longfei, PhD Candidate (12:45 p.m. to 1:15 p.m.)
Title: Periodontal and peri-implant microbiota in subjects with healthy and inflamed tissues

Abstract: Bacteria, in the form of biofilm, has been shown to play a critical role in the etiology and pathogenesis of periodontal and peri-implant infectious diseases. Studies have shown that distinctively different dental plaque is commonly found in healthy versus inflamed gingivae and mucosa. It should be noted, however, that in most of these studies, the healthy and diseased plaque samples were collected from different individuals. To address this important issue, subjects who were periodontally involved and/or had inflamed peri-implant tissues, and also had equivalent healthy control sites were recruited in my studies. The results indicated that there were larger differences in the composition of the microbial communities found in different individuals, than the differences in microbial composition found between the two sites with different probing depths in the same individual. The putative periodontal pathogens were identified both in healthy and inflamed tissues within the same subjects.

Presenter: Mr. Yau Tak Wai David, MPhil Candidate (1:15 p.m. to 1:45 p.m.)
Title: Bayesian Longitudinal Polytomous Item Response Models for Child Perception Questionnaire

Abstract: Traditional approach to measuring latent constructs is simple yet involving unrealistic assumptions. The item response theory (IRT) not only can circumvent the unrealistic assumptions, useful item and test properties can also be revealed. CPQ11-14 is a pioneer and widely adopted oral health-related quality of life (OHRQoL) instrument for children aged 11 to 14. This study aims to explore the CPQ11-14 psychometric properties by IRT and investigate factors affecting changes in OHRQoL over time. Of particular interests are the identification of potentially biased items, investigation of the reliability under the IRT framework and item discriminatory power.

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Aug 14 2014

Dental Research Seminar

Published by Dental Library under Dentistry
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Date: August 21, 2014 (Thursday)
Time: 12:45 p.m. to 1:45 p.m.
Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

Presenter: Dr. Yeung Wai Kan Andy, MPhil Candidate (12:45 p.m. to 1:15 p.m.)
Abstract: The perception of taste has been investigated by neuroimaging studies with the use of various liquid delivery systems. However, existing systems compatible with functional magnetic resonance imaging (fMRI) have limitations including limited tongue coverage and discontinuous liquid delivery. The aim of this study is to develop a delivery system which can deliver multiple solutions to a major portion of the dorsal and lateral surfaces of the tongue with a stable and continuous flow and a user-friendly interface. Results from a pilot study will also be shown to demonstrate the ability to detect brain activations triggered by taste stimuli.

Title: Development of a taste liquid delivery system for functional magnetic resonance imaging

 

Presenter: Miss Wu Lingli, MPhil Candidate (1:15 p.m. to 1:45 p.m.)

Title: Motivational Interviewing and Interactive Risk Assessment in Changing Adolescents’ Oral Health Behaviours: Process Evaluation and Randomized Controlled Trial

Abstract: The prevention of common oral diseases highly depends on one’s adoption of healthy behaviors. Conventional (oral health) education (CE) often fails to elicit sustainable changes in oral health behaviors. In this study, motivational interviewing (MI) and interactive risk assessment (RA) will be introduced for changing adolescents’ oral health behaviors. Through a randomized controlled trial, the effectiveness of three intervention schemes (CE, MI, and MI + RA) in enhancing adolescents’ oral health self-efficacy, improving their oral health habits (diet and oral hygiene), and preventing dental caries will be compared. Through process evaluations, the feasibility, acceptance, and quality of delivery of the respective interventions will be determined, whereas process factors that affect the effectiveness of the interventions will be identified. This study will involve 450 adolescents recruited from 15 secondary schools. Data will be collected at baseline and after 6, 12, and 24 months.

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Jun 17 2014

Dental Research Seminar

Published by Dental Library under Dentistry
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Date: June 23, 2014 (Monday)

Time: 12:45 p.m. to 1:30 p.m.

Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

 

Presenter: Ms. Ma Xiaomin, PhD Candidate

Title: Effects of Silver Diamine Fluoride in Preventing Dental Caries in Patients Wearing Removable Partial Dentures: A Randomized Double-blind, Placebo-controlled Study 

Abstract: Removable partial dentures (RPDs) are commonly used to replace missing teeth in adult patients. However, patients wearing dentures may have an increased rate of dental decay. The effect of topical fluoride on caries prevention in RPD wearers have not been evaluated in previous studies. The aim of this study is to compare the effectiveness of semi-annually applied silver diamine fluoride versus placebo on dental caries prevention and the quality of oral flora in patient wearing RPDs over a two-year period.

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Jun 12 2014

Dental Research Seminar

Published by Dental Library under Dentistry
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Date: June 18, 2014 (Wednesday)
Time: 12:45 p.m. to 1:30 p.m.
Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

Presenter: Mr. Yang Ning, PhD Candidate

Title: The stringent response in Staphylococcus aureus and related bacterial pathogens

Abstract: The stringent response is a coordinated regulatory process initiated by all bacterial species in response to starvation or environmental challenges, such as oxidative stress or antibiotic administration. In this talk, I will give an overview of the mechanisms underlying the stringent response, with particular emphasis to the major bacterial pathogen Staphylococcus aureus. I will outline the key molecular processes that remain to be fully elucidated, and will indicate how these issues may be addressed.

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May 28 2014

Dental Research Seminar

Published by Dental Library under Dentistry
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Date: June 4, 2014 (Wednesday)
Time: 12:45 p.m. to 1:45 p.m.
Venue: Lecture Theatre II, G/F, The Prince Philip Dental Hospital

Presenter: Miss Wang Shuai, PhD Candidate (12:45 p.m. to 1:15 p.m.)

Title: Effects of Enterococcus faecalis and Lipoteichoic Acid from Enterococcus faecalis on osteoblasts and osteoclasts

Abstract: Enterococcus faecalis is considered a major pathogen related to refractory root canal infection. E. faecalis colonize dentin and form biofilms in endodontically treated teeth with periapical lesions. Lipoteichoic acid (LTA) is a principal component of bacterial membrane and a major virulence factor of E. faecalis. LTA can cause apoptosis in osteoblasts and osteoclasts and stimulates leukocyte to release pro-inflammatory cytokines and bone resorption. Semaphorin 4D (Sema4D), is a mediator of osteoclast-osteoblast communication. Sema4D-Plexin-B1 bidirectional signaling plays a critical role in the suppression of osteoblast differentiation. In our present study, we for the first time have found that E. faecalis LTA induced the immune-inflammatory response of human macrophages via TLR-2 dependent NF-κB and p38 signal transduction. Furthermore, E. faecalis enhanced osteoclastogenesis with upregulation of Sema4D expression. Further studies are needed to explore the mechanisms of E. faecalis and E. faecalis LTA involved in osteogenensis, osteoclastogenesis and bidirectional signaling in bone remodeling.

 

Presenter: Mr. Jin Xiaozhuang, PhD Candidate (1:15 p.m. to 1:45 p.m.)

Title: Universal primers: Development and adhesion aspects for resin-metal bonding

Abstract: Currently, no single bonding agent could bond universally dental acrylic-based resin to metals. Recently, the novel silane system (NSS) primers were reported by Matinlinna and co-workers that could promisingly to promote the bonding between the resin and some dental biomaterials e.g. titanium and amalgam. NSS primers sought to provide a durable and hydrolytic stable bonding permanently. However, the adhesion mechanism and optimal formulation of NSS primers are not yet studied. Thus, in the current study, the mechanical, chemical and physical properties of such NSS primers would be studied in order to understand fundamentally the adhesion mechanism, and improve the NSS primers performance in acrylic-based resin to metal bonding. In addition, optimized NSS primers formulations which could universally enhance the bonding between acrylic-based resin and metals in both dental and medical systems are targeted. 

No responses yet| 153 views

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